Promethazine is metabolized with the liver to a range of inactive metabolites for instance sulfoxides of promethazine, N-demethylpromethazine together with other glucuronides.Promethazine has an elimination 50 %-lifetime of 10-14 hours, with excretion of metabolites showing up while in the urine and feces. The sulfoxides of promethazine and N-demet… Read More